Novas studias davart fendidas dal palat e malfurmaziuns craniofacialas — explicadas simplamain. Actualisà mintga mais da PubMed.
📅 Novs artitgels mintga mais: il emprim da mintga mais apparan qua las ultimas publicaziuns da PubMed — elavuradas automaticamain. Ultima actualisaziun: avust 2026.
10 artitgels · Proxima actualisaziun: 1. october 2026
ChirurgiaNovGenerà da l'IA, betg controllà professiunalmain2026-08
Success a lunga vista per tgirvel ed egls suenter l'operaziun d'ina craniosinostosa cun ina suatira sulaina
Salib AN, Kong V, Glaeser-Khan S, Allam O, Alperovich M
Journal of Craniofacial Surgery
🔍Tge suatira ch'è pertutgada di enavant il tip da ristg a lunga vista: la sinostosa sagittala augmenta il ristg per pressiun cerebrala augmentada, la sinostosa coronara singula il ristg per complicaziuns dals egls, la sinostosa lambdoidala il ristg per ina malformaziun da Chiari.
📋 Per geniturs e pazients
En questa gronda studia americana cun passa 1600 uffants operads per ina suatira cranica serrada han ils perscrutaders suandà tge complicaziuns a lunga vista èn cumparidas onns suenter l'operaziun. La suatira pertutgada faschet ina differenza: uffants cun sinostosa sagittala han pli savens sviluppà pressiun cerebrala augmentada, uffants cun sinostosa coronara singula pli savens problems dals egls, ed uffants cun sinostosa lambdoidala pli savens ina malformaziun da Chiari (in spustament sut vart d'ina part dal tgirvel). Quai fa supponer che la tgira suandanta duai vegnir adattada a la suatira pertutgada, cun controllas regularas era ditg suenter la emprima operaziun.
Anc betg disponibel en rumantsch — mussà en englais.
Tip da la studia: Retrospective cohort study using a national US database (Pediatric Health Information System), 2015-2024 (n = 1602 uffants)
Limitaziun: Administrative database without standardized clinical imaging; possible coding inaccuracies and missing data on synostosis severity.
Relevanza clinica: Postoperative surveillance after craniosynostosis surgery should be tailored by suture type, with targeted long-term monitoring for intracranial pressure, vision, or Chiari malformation.
This retrospective cohort study used the Pediatric Health Information System database to evaluate long-term intracranial and ophthalmologic outcomes in 1602 children with single-suture craniosynostosis treated surgically between 2015 and 2024 (mean follow-up 5.3±3.6 years). Sagittal synostosis was associated with elevated intracranial pressure (6.3%), unicoronal synostosis with ophthalmologic complications (23.6%), and lambdoid synostosis with Chiari I malformation (17.9%). Surgery performed at 1 to 2 years of age was associated with increased odds of elevated intracranial pressure and hydrocephalus.
ChirurgiaNovGenerà da l'IA, betg controllà professiunalmain2026-05
Plattina da gulti betg operativa cunter l'operaziun d'allungiar la mandibula tar la sequenza da Robin: cumparegliaziun dals custs d'ospital
Krakauer KN, Forrest CR, et al.
Cleft Palate-Craniofacial Journal
🔍Uffants pitschens tractads cun la plattina betg operativa han gì suandaments d'ospital pli curts e circa 46% pli bassa custs d'ospital ch'uffants tractads cun la distracziun mandibulara operativa.
📋 Per geniturs e pazients
La sequenza da Robin chaschuna tar nov-naschids ina mandibula pitschna e difficultads da respirar; dus tractaments frequents èn ina plattina da gulti che maina il svilup da la mandibula, u in'operaziun che allungia la mandibula cun in apparat da distracziun. Questa studia americana ha cumparegià 13 uffants pitschens tractads cun la plattina cun 9 tractads operativamain, e ha chattà che il grup cun plattina ha bandunà l'ospital pli baud e ha gì custs d'ospital considerablamain pli bass, surtut damai ch'els avevan gì basegn da damain tgira intensiva e nagina operaziun. Ils resultats pon gidar famiglias e teams da tractament ad evaluar in emprim access betg operativ, sche quai è medicalmain giustifitgabel.
Anc betg disponibel en rumantsch — mussà en englais.
Tip da la studia: Single-center retrospective cohort study, 2016-2023 (n = 22 pazients)
Limitaziun: Small sample (22 infants) from a single center; treatment choice was not randomized, so selection bias by severity is possible.
Relevanza clinica: In suitable cases of Robin sequence, a nonsurgical orthodontic airway plate can be an effective and less costly alternative to mandibular distraction surgery.
This single-center retrospective cohort study compared hospital charges and length of stay in infants with Robin sequence treated with a nonsurgical Stanford orthodontic airway plate (OAP, n=13) versus surgical mandibular distraction osteogenesis (MDO, n=9) between 2016 and 2023. Median total hospital stay was 15 days with OAP versus 23 days with MDO. Median inflation-adjusted hospital charges were substantially lower with OAP ($683,549) than MDO ($1,269,670), a 46.2% reduction, driven mainly by shorter ICU stay and lower operating-room utilization in the OAP group.
ChirurgiaNovGenerà da l'IA, betg controllà professiunalmain2026-02
Sindrom da Treacher Collins: ils emprims cas confermads geneticamain en famiglias mexicanas
et al. (Mexican research consortium)
International Journal of Molecular Sciences
🔍Tests genetics han identifitgà trais differentas variantas che chaschunan la malsogna en ils gens TCOF1 e POLR1D tar trais famiglias mexicanas cun sindrom da Treacher Collins - confermads per l'emprima giada en questa populaziun.
📋 Per geniturs e pazients
Il sindrom da Treacher Collins influenzescha co ils ossa da la fatscha, la mandibula e las uraglias sa svilupan, ed è chaschunà tras midadas en in pitschen dumber da gens enconuschids. Perscrutaders han examinà 11 persunas pertutgadas da trais famiglias mexicanas e confermà, tras ina sequenziaziun detagliada da l'DNA, la midada genetica responsabla en mintga famiglia. Quai è valurus, damai che la gronda part dals datas genetics publitgads davart quest sindrom vegnan da populaziuns europeas u nordamericanas - in maletg pli larg gida a far la consulenza genetica e ils tests pli fidads per famiglias da differenta origin en tut il mund.
Anc betg disponibel en rumantsch — mussà en englais.
Tip da la studia: Genetic case series: whole-exome sequencing with Sanger confirmation in 11 affected individuals from 3 families (n = 11 pazients)
Limitaziun: Very small sample (3 families); findings cannot be readily generalized to the entire Mexican population.
Relevanza clinica: Expands the known spectrum of TCOF1/POLR1D variants, improving genetic counseling and diagnostic accuracy for families of diverse backgrounds.
This study performed whole-exome sequencing followed by Sanger sequencing validation in eleven patients from three Mexican families with Treacher Collins syndrome. Family 1 carried a heterozygous pathogenic splice-site variant in TCOF1 (c.4345+1G>A), inherited maternally. Family 2 carried a heterozygous pathogenic TCOF1 frameshift variant (c.226_227insC, p.R77fs), inherited paternally. Family 3 carried a heterozygous pathogenic POLR1D variant (c.290_291delAG, p.G99fs) segregating in an autosomal dominant pattern across three generations. These represent the first molecularly confirmed Treacher Collins cases reported from the Mexican population.
ChirurgiaNovGenerà da l'IA, betg controllà professiunalmain2026-01
Miglurada operaziun da Z-plastica per l'insuffizienza velofaringeala marginala
Fukuyama S, Lo CC, Yamaguchi K, Lo LJ
Annals of Plastic Surgery
🔍L'agiunta d'ina prolungaziun dal palat mol ed ina transplantaziun da grass a la tecnica da Z-plastica dubla ha augmentà la quota da success da l'operaziun per cas pli levs d'insuffizienza velofaringeala che donnegia la favella da 80% a 100%.
📋 Per geniturs e pazients
Insuffizienza velofaringeala signifitgescha che il palat mol na serra betg endretg il nas durant il discurs, quai chaschuna ina vusch nasala; la Z-plastica dubla è ina tecnica operativa per corriger formas pli levas. Quest center taiwanais ha cumparegià 114 pazients tractads durant 17 onns e ha chattà che la megldraziun da la tecnica - l'emprim tras ina prolungaziun dal palat mol, lura tras ina pitschna transplantaziun da grass - ha augmentà cuntinuadamain la quota da success da 80% a 100% en il grup il pli nov, senza chaschunar problems da respirar u da durmir. Per famiglias avant in tal tip d'operaziun mussa quai che la tecnica operativa sa svilupa vinavant vers meglers resultats da favella cun damain complicaziuns.
Anc betg disponibel en rumantsch — mussà en englais.
Tip da la studia: Single-center retrospective case series comparing three technique generations, 2007-2024 (n = 114 pazients)
Limitaziun: Single-center, single-surgeon experience; no randomized allocation between technique generations.
Relevanza clinica: Shows that targeted technical refinements (lengthening, fat grafting) can substantially improve Z-plasty success rates for milder velopharyngeal insufficiency.
This retrospective study from a Taiwanese craniofacial center reviewed 114 patients with marginal velopharyngeal insufficiency (VPI) who underwent double-opposing Z-plasty (DOZ) between 2007 and 2024. Three generations of the technique were compared: the original DOZ, a modified version with additional soft palate lengthening, and a further modification adding fat grafting. Success rates were 80.4%, 88.6%, and 100% respectively, with no airway obstruction or sleep disturbance reported in the fat-grafting group.
ChirurgiaNovGenerà da l'IA, betg controllà professiunalmain2026-03
Operaziun d'avanzament da la mandibula superiura e ses effect sin la favella tar pazients cun sfessa dal palat
Singh DJ, et al.
Journal of Craniofacial Surgery
🔍L'avanzament operativ da la mandibula superiura po pejurar tar tscherts pazients cun sfessa dal palat curada l'insuffizienza velofaringeala che pertutga la favella - particularmain tenor sche gia dapli avant è vegnida fatga in'operaziun VPI.
📋 Per geniturs e pazients
Tscherts uffants cun sfessa dal palat curada dovran pli tard in'operaziun per avanzar la mandibula superiura (osteotomia LeFort I) per corriger ina fatscha central dombrada, quai po dentant a mumaints influenzar co bain il palat mol serra il nas durant il discurs. Questa pitschna studia americana ha suandà 21 pazients, tscherts senza operaziun VPI avant e tscherts cun in flap faringeal gia existent, e ha suandà midadas da la favella nasala e da la qualitad da vita suenter l'operaziun da la mandibula. Ils resultats gidan teams da operaziun e da logopedia a prevair e discuter il ristg da midadas da favella cur ch'ins planisescha in'operaziun d'avanzament da la mandibula, uschia che famiglias pon vegnir preparadas e logopedia organisada sche necessari.
Anc betg disponibel en rumantsch — mussà en englais.
Tip da la studia: Single-center retrospective cohort study comparing patients with and without prior VPI surgery (n = 21 pazients)
Limitaziun: Very small sample (21 patients) from a single center; limited statistical power.
Relevanza clinica: When planning jaw-advancement surgery, the risk of worsened speech should be discussed and speech-therapy follow-up planned.
This single-center retrospective cohort study examined changes in velopharyngeal insufficiency (VPI) symptoms following LeFort I maxillary advancement osteotomy in 21 patients with repaired cleft palate, comparing those with no prior VPI surgery (n=10) to those with a pre-existing pharyngeal flap (n=11). Outcomes measured included hypernasality, audible nasal emission, and VPI-related quality of life (VELO-Y questionnaire) before and after surgery.
OrtodonziaNovGenerà da l'IA, betg controllà professiunalmain2026-03
Implants dentals en mandiblas pertutgadas d'ina sfessa: las quotas da success sa migliuran cuntinuadamain
Tent A, Mester A, Gabriel A, Bran S, Sabau D, Piciu A, Onisor F
Medicina (Kaunas)
🔍En 18 studias cun passa 1500 implants dentals messos en lieus da mandibla pertutgads d'ina sfessa e transplantads, la quota da success dals implants è sa migliurada da circa 91% en studias pli baud a 94% en studias pli novas.
📋 Per geniturs e pazients
Suenter ch'ina transplantaziun d'ossa ha serrà la fessura en la mandibla d'ina persuna cun sfessa, po in implant dental pli tard remplazzar in dent ch'è mancant en quest lieu. Questa survista ha resumà resultats da 18 studias cun passa 1500 implants e ha chattà che las quotas da success sa sun cuntinuadamain migliuradas cun il temp, ussa en media circa 94% en perscrutaziuns novas - cumparegliabel cun implants messos en mandiblas senza sfessa. La gronda part dals fallimaints ha capità baud, en ils emprims mais, e steva en connex cun memia pauc ossa u stabilitad insuffizienta tar l'inserziun, quai suttastrichescha l'impurtanza d'in bun timing e d'ina tecnica accurata.
Anc betg disponibel en rumantsch — mussà en englais.
Tip da la studia: Systematic review of 18 clinical studies (PRISMA methodology) (n = 18 studias)
Limitaziun: Substantial heterogeneity among included studies in follow-up duration and implant systems used.
Relevanza clinica: Confirms dental implants after alveolar bone grafting as a reliable option in cleft dental rehabilitation, given careful planning of graft volume and timing.
This systematic review analyzed 18 clinical studies representing 1561 dental implants placed in bone-grafted alveolar cleft sites in patients with cleft lip, alveolus, and/or palate. Overall reported implant survival ranged from 80% to 100%. Weighted pooled survival improved from 91.2% in earlier studies to 94.2% in more recent cohorts, a statistically significant 3.0 percentage-point improvement. Implant failures occurred mainly during early osseointegration and were commonly linked to insufficient graft volume or inadequate primary stability.
OrtodonziaNovGenerà da l'IA, betg controllà professiunalmain2026-04
Cussegls practics per dentists generals che tractan pazients cun sfessa da la lavra e dal palat
Mohelay N, Batra P, Seeballuck C, Dominguez M, Mossey P
British Dental Journal
🔍Dentists generals giogan in roll preventiv decisiv per persunas cun sfessa da la lavra e dal palat, che han considerablamain pli savens caries e malsognas da la schuma da dents che la populaziun generala.
📋 Per geniturs e pazients
Persunas naschidas cun sfessa da la lavra e dal palat han savens dapli difficultads da tegnair dents e schuma da dents sauns - part per l'anatomia pertutgada, part per ils bleras tractaments ch'ellas passan tras. Quest cussegl per dentists generals suttastrichescha ch'in'annunzia baud tar in studi dental, cuntachs stretgs cun il team spezialisà da la sfessa, ed in plan da prevenziun individual per caries e la sanadad da la schuma da dents pon reducir considerablamain quests problems, ch'èn per gronda part evitabels. Quai regorda a famiglias che il dentist local u da famiglia resta ina part impurtanta dal team da tractament - vi da la clinica spezialisada da sfessas.
Anc betg disponibel en rumantsch — mussà en englais.
Tip da la studia: Clinical guidance article / expert recommendations for general dental practice
Limitaziun: Not a systematic review of primary data, but an expert-opinion-based practice guide.
Relevanza clinica: Highlights the role of the local general dental practice as an important link to specialist cleft follow-up care for caries prevention.
This clinical guidance article outlines practical recommendations for general dental practitioners managing patients with cleft lip and/or palate, who face disproportionately higher rates of dental caries and periodontal disease. It emphasizes early registration with dental services, coordinated communication with the specialist cleft multidisciplinary team, and tailored preventive strategies covering caries and oral hygiene, to reduce the burden of largely preventable dental problems in this population.
LogopediaNovGenerà da l'IA, betg controllà professiunalmain2026-05
Distinguer problems da favella structurals da problems funcziunals tar la tgira da sfessas
Kinter S, Beckett L, Bly RA
Oral and Maxillofacial Surgery Clinics of North America
🔍La tractaziun correcta da problems da favella chaschunads da la sfessa dependa dal fatg sche la chaschun è structurala (operaziun necessaria) u funcziunala (logopedia necessaria) - in'evaluaziun che vegn fatga il meglier ensemen dal chirurg e da la logopedista.
📋 Per geniturs e pazients
Sche in uffant cun sfessa dal palat curada ha difficultads da discurrer cler, n'è betg adina cler sche il problem sta en l'anatomia dal palat (structural) u en costums da discurrer emprendids (funcziunal) - omaduas dumondan dentant tractaments fitg differents. Quest artitgel explitgescha co ina logopedista evaluescha il muster da favella e collavura cun il team chirurgic per chattar la chaschun: Problems structurals sco l'insuffizienza velofaringeala pon dumandar in'operaziun u ina plattina da palat, entant che musters funcziunals sco l'emprender fauss velofaringeal reageschan mo cun logopedia mirada. Per famiglias suttastritgescha quai, pertge ina diagnosa exacta dal team cumbinà da chirurgia e logopedia è impurtanta avant la decisiun tranter operaziun e terapia.
Anc betg disponibel en rumantsch — mussà en englais.
Tip da la studia: Narrative clinical review
Limitaziun: Not a systematic literature review with defined inclusion/exclusion criteria, but a clinically oriented summary.
Relevanza clinica: Emphasizes the need for joint surgical and speech-language evaluation before deciding between surgery and speech therapy.
This review outlines the management of cleft-related speech differences, emphasizing the need for careful differential diagnosis to distinguish structural causes (such as velopharyngeal insufficiency, requiring surgery or a prosthetic device) from functional causes (such as velopharyngeal mislearning, addressed with speech therapy). A specialized speech-language pathologist performs perceptual evaluation, and management requires close collaboration between the surgeon and speech-language pathologist.
OrtodonziaNovGenerà da l'IA, betg controllà professiunalmain2026-07
Co ina sfessa dal palat sulaina furma il profil dal nas tar giuvens creschids
Zawislak A, Jankowska A, Jankowski T, Grocholewicz K, Janiszewska-Olszowska J
Folia Morphologica
🔍Giuvens creschids cun sfessa dal palat sulaina (senza participaziun da la lavra) mussan en cumparegliaziun cun persunas senza sfessa caracteristicas dal nas e da la fatscha centrala mesirablamain pli pitschnas e pli plattas - schebain che la lavra sezza n'è mai stada pertutgada.
📋 Per geniturs e pazients
Tar ina sfessa dal palat sulaina (CPO), nua ch'ei mo il palat ed betg la lavra è pertutgà, sa supponescha savens che l'aspect da la fatscha resta relativamain betg influenzà en cumparegliaziun cun ina sfessa cumbinada da la lavra e dal palat. Questa studia ha cumparegià mesiraziuns radiologicas detagliadas dal nas e da la fatscha centrala tar 59 giuvens creschids cun CPO e 59 persunas senza sfessa e ha chattà differenzas constantas e mesirablas: in dies dal nas pli platt, in nas pli curt ed in profil da la fatscha centrala pli platt en il grup CPO. Quai gida explitgar differenzas fines en l'aspect da la fatscha, che tscherts pazients remarcheschan era senza cicatrisch da la lavra, e po sustegnair la planisaziun ortodontica e chirurgica per quest grup.
Anc betg disponibel en rumantsch — mussà en englais.
Tip da la studia: Cross-sectional study with matched controls, cephalometric radiographic analysis (n = 118 participants)
Limitaziun: Only young adults (16-25 years) studied; no data on changes across childhood and adolescence.
Relevanza clinica: Shows that even an isolated cleft palate measurably affects nasal and midface profile - relevant for orthodontic and aesthetic counseling.
This cross-sectional study compared nasal and soft tissue cephalometric profiles between 59 young adults (16-25 years) with cleft palate only (CPO) and 59 matched controls. Patients with CPO showed a smaller nose-lip angle, shorter dorsum axis, and reduced nose length, along with smaller nasal depth and nasal bone length, larger nasal bone angle and nasomaxillary angle, and reduced soft tissue facial convexity, indicating an overall flatter midface profile compared with controls.
ChirurgiaNovGenerà da l'IA, betg controllà professiunalmain2026-05
Sfessa da la lavra e dal palat colliada cun pli autas quotas da malsognas psichicas
Lorenz FJ, Ma C, Parikh AC, Lighthall JG
Cleft Palate-Craniofacial Journal
🔍Uffants e creschids cun sfessa da la lavra e dal palat han retschet considerablamain pli savens che coetans senza sfessa la diagnosa depressiun, malsogna d'aunghels, ADHD u disturbi da cumportament - particularmain sche era problems da udir eran preschents.
📋 Per geniturs e pazients
Questa gronda studia americana ha cumparegià passa 56'000 uffants e creschids cun sfessa da la lavra e dal palat cun persunas senza sfessa e ha chattà considerablamain pli autas quotas da depressiun, malsogna d'aunghels, ADHD e disturbis da cumportament en il grup da sfessa, ensemen cun pli frequentas prescripziuns da medicaments correspundents. Il ristg era anc pli aut tar uffants che avevan er problems da udir sco liquid en l'ureglia media, quai che capita savens tar sfessas dal palat. Ils resultats sustegnan in screening da routine per malsognas psichicas e da cumportament sco part da la tgira suandanta normala dal team da sfessa - betg mo il suandament da resultats corporals e da favella.
Anc betg disponibel en rumantsch — mussà en englais.
Tip da la studia: Retrospective cohort study using a large US health-records database (n = 45341 uffants)
Limitaziun: Administrative database lacking clinical detail on cleft severity or psychosocial contributing factors.
Relevanza clinica: Supports routine psychosocial screening as part of cleft team follow-up, especially when hearing problems coexist.
This retrospective cohort study used a large US health-records database to compare the prevalence of mental health and behavioral disorders between individuals with cleft lip and/or palate (CL/P) and matched controls, including 45,341 pediatric and 10,855 adult participants with CL/P. Individuals with CL/P had significantly higher rates of depressive episodes, anxiety disorders, ADHD, and disruptive disorders, and were more often prescribed mental health medications and stimulants (all P<.001). Pediatric participants with cleft palate and coexisting conductive hearing loss or otitis media with effusion showed even higher rates of these disorders.
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